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BRACO 19 trihydrochloride

Names

[ CAS No. ]:
1177798-88-7

[ Name ]:
BRACO 19 trihydrochloride

[Synonym ]:
N,N'-(9-{[4-(Dimethylamino)phenyl]amino}-3,6-acridinediyl)bis[3-(1-pyrrolidinyl)propanamide] trihydrochloride
1-Pyrrolidinepropanamide, N,N'-[9-[[4-(dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-, hydrochloride (1:3)
BRACO-19
N,N'-(9-(4-(Dimethylamino)phenylamino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide) hydrochloride
BRACO19 hydrochloride
MFCD23380200

Biological Activity

[Description]:

BRACO-19 is a potent small molecule Telomerase inhibitor (IC50=115 nM) that inhibits expression of human telomerase reverse transcriptase (hTERT); induces cellular senescence and inhibits growth of uterine cancer cells in vitro, inhibits growth of uterine tumor xenografts in vivo.

[References]

References 1. Gowan SM, et al. Mol Pharmacol. 2002 May;61(5):1154-62. 2. Burger AM, et al. Cancer Res. 2005 Feb 15;65(4):1489-96. 3. Incles CM, et al. Mol Pharmacol. 2003 Nov;64(5):1101-8. 4. Gunaratnam M, et al. Biochem Pharmacol. 2009 Jul 15;78(2):115-22. View Related Products by Target Telomerase

Chemical & Physical Properties

[ Molecular Formula ]:
C35H46Cl3N7O2

[ Molecular Weight ]:
703.144

[ Exact Mass ]:
701.277832

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds