Z-505 hydrochloride

Z-505 hydrochloride is a novel, orally active ghrelin (GHSR1a) agonist with EC50 of 2.08 nM and 5.46 nM for rat and mouse GHSR1a, respectively;attenuates the progression of cancer cachexia via anabolic hormones in vivo, significantly improves the cisplatin-induced reduction in food intake and body weight, prevents the 5-FU-induced decrease in food intake and body weight in the 5-FU-induced mouse model.

References 1. Shiomi Y, et al. Eur J Pharmacol. 2018 Jan 5;818:148-157. 2. Yoshimura M, et al. Eur J Pharmacol. 2017 Sep 15;811:30-37. View Related Products by Target Ghrelin Receptor (GHSR)