1,3,3 TRIMETHYL-2-METHYLENE INDOLINE

Names

[ CAS No. ]:
118-12-7

[ Name ]:
1,3,3 TRIMETHYL-2-METHYLENE INDOLINE

[Synonym ]:
1,3,3-trimethyl-2-methylideneindole
1,3,3-TriMethyl-2-Methyleneindoline
MFCD00005813
EINECS 204-235-1
Fischer's Base
2-Methylene-1,3,3-trimethylindoline,Fischer base
1,3,3 TRIMETHYL-2-METHYLENE INDOLINE

Chemical & Physical Properties

[ Density]:
0.979 g/mL at 25 °C(lit.)

[ Boiling Point ]:
248 °C(lit.)

[ Melting Point ]:
-8 °C

[ Molecular Formula ]:
C₁₂H₁₅N

[ Molecular Weight ]:
173.25400

[ Flash Point ]:
215 °F

[ Exact Mass ]:
173.12000

[ PSA ]:
3.24000

[ LogP ]:
2.99270

[ Vapour Pressure ]:
0.0249mmHg at 25°C

[ Index of Refraction ]:
n20/D 1.577(lit.)

[ Water Solubility ]:
negligible

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM1926500

CHEMICAL NAME :: Indoline, 2-methylene-1,3,3-trimethyl-

CAS REGISTRY NUMBER :: 118-12-7

BEILSTEIN REFERENCE NO. :: 0131162

LAST UPDATED :: 199710

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C12-H15-N

MOLECULAR WEIGHT :: 173.28

WISWESSER LINE NOTATION :: T56 BNY DHJ B1 CU1 D1 D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#07782 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6185 No. of Facilities: 45 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 775 (estimated) No. of Female Employees: 20 (estimated)

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H400

[ Precautionary Statements ]:
P273

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R38;R50/53

[ Safety Phrases ]:
S28-S60-S61-S57-S37

[ RIDADR ]:
UN 3082 9/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
NM1926500

[ Hazard Class ]:
9.0

[ HS Code ]:
29339990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Angew. Chem. Int. Ed. Engl. 66 , 555, (1954)

Ishmetova, R., I.; et al.

Heterocycles 83 , 1363, (2011)

York, M.; Evans, R., A.

Tetrahedron Lett. 51 , 2195, (2010)