2-(Hydroxymethyl)isoindoline-1,3-dione

Names

[ CAS No. ]:
118-29-6

[ Name ]:
2-(Hydroxymethyl)isoindoline-1,3-dione

[Synonym ]:
1H-Isoindole-1,3(2H)-dione, 2-(hydroxymethyl)-
2-(Hydroxymethyl)-1H-isoindole-1,3(2H)-dione
PHTHALIMIDOMETHANOL
phthalimidomethyl alcohol
oxymethylphthalimide
N-(Hydroxymethyl)phthalimide
N-Hydroxymethylphthalimide
Phthalimidylmethanol
Hydroxymethyl Phthalimide
Methanol,phthalimido
AURORA KA-454
IFLAB-BB F0777-0575
N-Methylolphthalimide
Phthalimide, N- (hydroxymethyl)-
MFCD00005899
EINECS 204-241-4

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
332.0±25.0 °C at 760 mmHg

[ Melting Point ]:
147-149 °C(lit.)

[ Molecular Formula ]:
C₉H₇NO₃

[ Molecular Weight ]:
177.157

[ Flash Point ]:
154.6±23.2 °C

[ Exact Mass ]:
177.042587

[ PSA ]:
57.61000

[ LogP ]:
0.76

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.644

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TI5270000

CHEMICAL NAME :: Phthalimide, N-(hydroxymethyl)-

CAS REGISTRY NUMBER :: 118-29-6

BEILSTEIN REFERENCE NO. :: 0140946

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H7-N-O3

MOLECULAR WEIGHT :: 177.17

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 300 mg/kg

SEX/DURATION :: female 13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 48(10),64,1983

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
TI5270000

[ HS Code ]:
29251995

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Synthesis and anti-inflammatory activity of N-phthalimidomethyl 2,3-dideoxy- and 2,3-unsaturated glycosides.

Carbohydr. Res. 342(9) , 1169-74, (2007)

3,4,6-Tri-O-acetyl-D-galactal, 3,4,6-tri-O-acetyl-D-glucal and 3,6,2',3',4'6'-hexa-O-acetyl-D-lactal were reacted with N-hydroxymethylphthalimide and boron trifluoride etherate to produce the correspo...

Aqueous degradation of N-(hydroxymethyl)phthalimide in the presence of specific and general bases. Kinetic assessment of N-hydroxymethyl derivatives of nitrogen heterocycles as possible prodrugs.

J. Pharm. Biomed. Anal. 7(6) , 685-91, (1989)

The conversion of N-(hydroxymethyl)phthalimide (NHPH) to phthalimide could not be detected within 300 s at pH 9.0, whereas in 0.18 M NaOH complete conversion of NHPH to phthalimide was observed within...

[Effect of hydroxymethylphthalimide on embryogenesis in white rats].

Gig. Sanit. (10) , 64-6, (1983)