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Volvaltrate B

Names

[ CAS No. ]:
1181224-13-4

[ Name ]:
Volvaltrate B

[Synonym ]:
Butanoic acid, 3-methyl-2-(3-methyl-1-oxobutoxy)-, [(1S,4aR,6S,7S,7aS)-6-(acetyloxy)-7-(chloromethyl)-1,4a,5,6,7,7a-hexahydro-4a,7-dihydroxy-1-(3-methyl-1-oxobutoxy)cyclopenta[c]pyran-4-yl]methyl ester, (2R)-
{(1S,4aR,6S,7S,7aS)-6-Acetoxy-7-(chloromethyl)-4a,7-dihydroxy-1-[(3-methylbutanoyl)oxy]-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-yl}methyl (2R)-3-methyl-2-[(3-methylbutanoyl)oxy]butanoate

Biological Activity

[Description]:

Volvaltrate B is an anticancer agent, iridoid, can be obtained from the root of valerian (Valeriana officinalis). Volvaltrate B is effective against ovarian tumors in female mice. Volvaltrate B has the potential to study cancer[1][2].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Tan YZ, et al. Iridoids from Valeriana jatamansi induce autophagy-associated cell death via the PDK1/Akt/mTOR pathway in HCT116 human colorectal carcinoma cells. Bioorg Chem. 2019 Jun;87:136-141.  

[2]. Wang PC, et al. Iridoids and sesquiterpenoids from the roots of Valeriana officinalis. J Nat Prod. 2009 Sep;72(9):1682-5.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
632.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C27H41ClO11

[ Molecular Weight ]:
577.06

[ Flash Point ]:
336.2±31.5 °C

[ Exact Mass ]:
576.233765

[ PSA ]:
154.89000

[ LogP ]:
3.13

[ Vapour Pressure ]:
0.0±4.2 mmHg at 25°C

[ Index of Refraction ]:
1.526

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds