N-methylacrylamide
Names
[ CAS No. ]:
1187-59-3
[ Name ]:
N-methylacrylamide
[Synonym ]:
N-Methyl-2-propenamide
2-Propenamide,N-methyl
N-methylprop-2-enamide
EINECS 214-700-0
(meth-)acrylamide
2-Propenamide, N-methyl-
N-Methyl-acrylamid
N-Methylacrylamide
Acrylamide,N-methyl
Chemical & Physical Properties
[ Density]:
0.9±0.1 g/cm3
[ Boiling Point ]:
207.7±13.0 °C at 760 mmHg
[ Molecular Formula ]:
C4H7NO
[ Molecular Weight ]:
85.104
[ Flash Point ]:
103.6±4.8 °C
[ Exact Mass ]:
85.052765
[ PSA ]:
29.10000
[ LogP ]:
-0.68
[ Vapour Pressure ]:
0.2±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.415
[ Storage condition ]:
2-8°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AS3676000
- CHEMICAL NAME :
- Acrylamide, N-methyl-
- CAS REGISTRY NUMBER :
- 1187-59-3
- BEILSTEIN REFERENCE NO. :
- 1737696
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C4-H7-N-O
- MOLECULAR WEIGHT :
- 85.12
- WISWESSER LINE NOTATION :
- 1U1VM1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 476 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 477 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6500 mg/kg/13W-I
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - structural change in nerve or sheath Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - muscle weakness
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4988 mg/kg/18W-C
- TOXIC EFFECTS :
- Behavioral - muscle weakness
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2587 mg/kg/8W-I
- TOXIC EFFECTS :
- Related to Chronic Data - changes in testicular weight
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2544 mg/kg
- SEX/DURATION :
- male 16 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 595 gm/kg
- SEX/DURATION :
- male 5 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 595 gm/kg
- SEX/DURATION :
- male 5 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 596 mg/kg/5W (Continuous)
- REFERENCE :
- ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 59,201,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1046 No. of Facilities: 122 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 367 (estimated)
Safety Information
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
R20/21/22
[ Safety Phrases ]:
S23;S26;S36/S37/S39
[ RIDADR ]:
UN 2810
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
2924199090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2924199090
[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%