N'-(5-Bromo-2-hydroxybenzylidene)-4-methylbenzenesulfonohydrazide

Names

[ Name ]:
N'-(5-Bromo-2-hydroxybenzylidene)-4-methylbenzenesulfonohydrazide

[Synonym ]:
EINECS 657-003-0

Biological Activity

[Description]:

dCeMM1 is a RBM39 glue degrader. dCeMM1 shows functions by re-directing the activity of the CRL4DCAF15 ligase. dCeMM1 decreases the expression of RBM39 levels in WT KBM7 cells[1].

[Related Catalog]:

Research Areas >> Cancer

[In Vitro]

dCeMM1 (0-100 µM; 3 days) 抑制细胞生长，WT 和 UBE2Mmut KBM7 细胞的 EC50 分别为 3、8 µM[1 ]. dCeMM1 (10 µM; 12, 16 h) 降低 WT KBM7 细胞中 RBM39 的表达水平[1]。 Western Blot Analysis[1] Cell Line: WT and UBE2Mmut KBM7 cells Concentration: 10 µM Incubation Time: 12, 16 h Result: Decreased the expression of RBM39 levels in WT KBM7 cells.

[References]

[1]. Mayor-Ruiz C, et al. Rational discovery of molecular glue degraders via scalable chemical profiling. Nat Chem Biol. 2020 Nov;16(11):1199-1207.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
509.6±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₃BrN₂O₃S

[ Molecular Weight ]:
369.23

[ Flash Point ]:
262.0±32.9 °C

[ Exact Mass ]:
367.983032

[ LogP ]:
4.53

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.637

[ Storage condition ]:
2-8°C

N'-(5-Bromo-2-hydroxybenzylidene)-4-methylbenzenesulfonohydrazide

Names

Biological Activity

Chemical & Physical Properties

Related Compounds