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Dorzagliatin

Names

[ CAS No. ]:
1191995-00-2

[ Name ]:
Dorzagliatin

[Synonym ]:
(2S)-2-[4-(2-Chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]-N-{1-[(2R)-2,3-dihydroxypropyl]-1H-pyrazol-3-yl}-4-methylpentanamide
X59W6980E8
1H-Pyrrole-1-acetamide, 4-(2-chlorophenoxy)-N-[1-[(2R)-2,3-dihydroxypropyl]-1H-pyrazol-3-yl]-2,5-dihydro-α-(2-methylpropyl)-2-oxo-, (αS)-
dorzagliatin
10511

Biological Activity

[Description]:

Dorzagliatin (HMS5552), a dual-acting glucokinase (GK) activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Glucokinase
Research Areas >> Metabolic Disease

[Target]

Glucokinase[1]


[In Vivo]

Dorzagliatin (low-dose 10 mg/kg, and high-dose 30 mg/kg; administered intragastrically; daily 8:00 AM for one month) exerts a glucose-lowering effect on the glucose levels in diabetic rats[2. Animal Model: Male Sprague-Dawley (SD) rats (aged approximately 6–8 weeks and weighing 200-230 g)[2 Dosage: Low-dose (10 mg/kg), and high-dose (30 mg/kg) Administration: Administered intragastrically (i.g.); daily (8:00 AM) for one month Result: Exerted a glucose-lowering effect on the glucose levels.

[References]

[1]. Zhu XX, et al. Dorzagliatin (HMS5552), a novel dual-acting glucokinase activator, improves glycaemic control and pancreatic β-cell function in patients with type 2 diabetes: A 28-day treatment study using biomarker-guided patient selection. Diabetes Obes Metab. 2018 Sep;20(9):2113-2120.

[2]. Wang P, et al. Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus. J Diabetes Res. 2017;2017:5812607.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
761.7±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H27ClN4O5

[ Molecular Weight ]:
462.927

[ Flash Point ]:
414.5±32.9 °C

[ Exact Mass ]:
462.166992

[ LogP ]:
2.78

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.631

Related Compounds