1-amino-2-naphthol hydrochloride

Names

[ Name ]:
1-amino-2-naphthol hydrochloride

[Synonym ]:
1-Amino-2-naphthol Hydrochloride
EINECS 214-830-8
1-Amino-2-naphtholhydrochloride
MFCD00012561
1-Aminonaphthalen-2-ol hydrochloride
1-aminonaphthalen-2-ol,hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
336.8ºC at 760mmHg

[ Melting Point ]:
250 °C (dec.)(lit.)

[ Molecular Formula ]:
C₁₀H₁₀ClNO

[ Molecular Weight ]:
195.64500

[ Flash Point ]:
157.5ºC

[ Exact Mass ]:
195.04500

[ PSA ]:
46.25000

[ LogP ]:
3.51080

[ Vapour Pressure ]:
5.61E-05mmHg at 25°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL3335000

CHEMICAL NAME :: 2-Naphthol, 1-amino-, hydrochloride

CAS REGISTRY NUMBER :: 1198-27-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C10-H9-N-O.Cl-H

MOLECULAR WEIGHT :: 195.66

WISWESSER LINE NOTATION :: L66J BZ CQ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 500 ug/well/16H

REFERENCE :: CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 15,219,1976

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332-H315-H319-H335-H351

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R20/21/22;R36/37/38;R40

[ Safety Phrases ]:
S26-S27-S36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
QL3335000

[ HS Code ]:
2922299090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Anaerobic metabolism of 1-amino-2-naphthol-based azo dyes (Sudan dyes) by human intestinal microflora.

Appl. Environ. Microbiol. 73(23) , 7759-62, (2007)

The rates of metabolism of Sudan I and II and Para Red by human intestinal microflora were high compared to those of Sudan III and IV under anaerobic conditions. Metabolites of the dyes were identifie...

Evaluation of impact of exposure of Sudan azo dyes and their metabolites on human intestinal bacteria.

Anaerobe 18(4) , 445-53, (2012)

Sudan azo dyes are banned for food usage in most countries, but they are illegally used to maintain or enhance the color of food products due to low cost, bright staining, and wide availability of the...

Effects of Orange II and Sudan III azo dyes and their metabolites on Staphylococcus aureus.

J. Ind. Microbiol. Biotechnol. 38(10) , 1729-38, (2011)

Azo dyes are widely used in the plastic, paper, cosmetics, food, and pharmaceutical industries. Some metabolites of these dyes are potentially genotoxic. The toxic effects of azo dyes and their potent...