7-Chloro-4-quinolinamine

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
366.8±27.0 °C at 760 mmHg

[ Melting Point ]:
96-97°C

[ Molecular Formula ]:
C₉H₇ClN₂

[ Molecular Weight ]:
178.618

[ Flash Point ]:
175.7±23.7 °C

[ Exact Mass ]:
178.029770

[ PSA ]:
38.91000

[ LogP ]:
2.38

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.712

[ Water Solubility ]:
REACTS

Click to get detail MSDS

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H319

[ Precautionary Statements ]:
P301 + P310-P305 + P351 + P338

[ Hazard Codes ]:
C

[ Risk Phrases ]:
R34:Causes burns. R40:Limited evidence of a carcinogenic effect. R14:Reacts violently with water.

[ Safety Phrases ]:
S23-S24/25-S26-S36/37/39-S45-S22

[ RIDADR ]:
UN 3265 8/PG 2

[ WGK Germany ]:
2

[ RTECS ]:
RR4584700

[ Packaging Group ]:
II

[ Hazard Class ]:
4.1

[ HS Code ]:
29420000

Click to get detail synthetic route

Precursor

DownStream

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Overcoming drug resistance to heme-targeted antimalarials by systematic side chain variation of 7-chloro-4-aminoquinolines.

J. Med. Chem. 51(7) , 1995-8, (2008)

Systematic variation of the branching and basicity of the side chain of chloroquine yielded a series of new 7-chloro-4-aminoquinoline derivatives exhibiting high in vitro activity against four differe...

New chimeric antimalarials with 4-aminoquinoline moiety linked to a tetraoxane skeleton.

J. Med. Chem. 51(19) , 6216-9, (2008)

The synthesis of the chimeric molecules consisting of two pharmacophores, tetraoxane and 7-chloro-4-aminoquinoline, is reported. The tetraoxanes 2, 4, and 8 show relatively potent in vitro antimalaria...

An ELISA test for detecting chloroquine in urine.

Trans. R. Soc. Trop. Med. Hyg. 82(2) , 216-20, (1988)

Two ELISA tests for detecting chloroquine in urine have been developed using polyclonal and monoclonal antibodies which react with the 7-chloro-4-amino-quinoline part of the chloroquine molecule and t...

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