Retro 2

Names

[ CAS No. ]:
1201652-50-7

[ Name ]:
Retro 2

[Synonym ]:
2-{(E)-[(5-Methyl-2-thienyl)methylene]amino}-N-phenylbenzamide
2-{[(E)-(5-methylthiophen-2-yl)methylidene]amino}-N-phenylbenzamide
MFCD01042512
Benzamide, 2-[[(1E)-(5-methyl-2-thienyl)methylene]amino]-N-phenyl-

Biological Activity

[Description]:

Retro 2 is the first small molecule inhibitor of plant toxin ricin, protects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endosome-TGN (trans-Golgi network) interface; has no effect on endogenous retrograde cargo proteins; protects mice against ricin challenge.

[References]

References 1. Stechmann B, et al. Cell. 2010 Apr 16;141(2):231-42. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
461.9±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₆N₂OS

[ Molecular Weight ]:
320.408

[ Flash Point ]:
233.2±27.3 °C

[ Exact Mass ]:
320.098328

[ LogP ]:
4.16

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.629

Retro 2

Names

Biological Activity

Chemical & Physical Properties

Related Compounds