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Diethyl 1-benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate

Names

[ CAS No. ]:
120533-76-8

[ Name ]:
Diethyl 1-benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate

[Synonym ]:
.diethyl 1-benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate

Biological Activity

[Description]:

BML-278 is a SIRT1 activator (EC150: 1 μM). BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in both the paternal and maternal pronucleus. BML-278 improves early embryonic development. BML-278 arrests the cell cycle at the G1/S phase, and reduces senescence in primary human mesenchymal cells. BML-278 reduces tubulin acetylation in U937 cells. BML-278 also increases mitochondrial density in murine C2C12 myoblasts[1][2].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin
Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Histone Methyltransferase
Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin

[Target]

SIRT1[1].


[References]

[1]. Adamkova K, et al. SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9 (H3K9) in the zygotic pronuclei improves porcine embryo development. J Anim Sci Biotechnol. 2017 Nov 1;8:83.  

[2]. Mai A, et al. Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors. J Med Chem. 2009 Sep 10;52(17):5496-504.  

Chemical & Physical Properties

[ Molecular Formula ]:
C24H25NO4

[ Molecular Weight ]:
391.46

[ Exact Mass ]:
391.17800

[ PSA ]:
55.84000

[ LogP ]:
4.11790

Precursor & DownStream

Precursor

DownStream