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BMN-673 (8R,9S)

Names

[ CAS No. ]:
1207456-00-5

[ Name ]:
BMN-673 (8R,9S)

[Synonym ]:
(8R,9S)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one
BMN-673 8R,9S||BMN673 (8R,9S)|BMN 673 (8R,9S)
BMN 673 (8R,9S)
CS-1223
BMN-673 (8R,9S)

Biological Activity

[Description]:

Talazoparib 8R,9S (BMN-673 8R,9S) is an enantiomer of Talazoparib, less active than Talazoparib on the inhibition of PARP1, with an IC50 of 144 nM.

[Related Catalog]:

Research Areas >> Cancer

[Target]

PARP-1:144 nM (IC50)


[References]

[1]. Wang B, et al. Discovery and Characterization of (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-


[Related Small Molecules]

Talazoparib | XAV-939 | MK-4827(Niraparib) | Veliparib (ABT-888) | Rucaparib (AG-014699) phosphate | PJ34 HCl | Pamiparib | Rucaparib camsylate | E-7449 | AZD2461 | G007-LK | Iniparib (BSI-201) | NMS-P118 | A-966492 | AG14361

Chemical & Physical Properties

[ Molecular Formula ]:
C19H14F2N6O

[ Molecular Weight ]:
380.35100

[ Exact Mass ]:
380.12000

[ PSA ]:
91.98000

[ LogP ]:
1.89830

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds