SR 7826
Names
[ CAS No. ]:
1219728-20-7
[ Name ]:
SR 7826
[Synonym ]:
MFCD29081182
1-(2-Hydroxyethyl)-3-[4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-1-phenylurea
Urea, N-(2-hydroxyethyl)-N'-[4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-N-phenyl-
Biological Activity
[Description]:
SR7826 is a potent and selective LIM kinase (LIMK) inhibitor with IC50 of 43 nM, displays >100-fold selectivity over ROCK1 and ROCK2, as well as JNK kinases (>400-fold); inhibits only Limk1 and STK16 with >80% inhibition at 1 uM in a panel of 61 kinases; potently inhibits cofilin phosphorylation in A7r5, PC-3, and CEM-SS T cells (IC50 <1 uM), suppresses migration and invasion of PC-3 cells in vitro.
[References]
References 1. Yu Q, et al. Br J Pharmacol. 2018 Jun;175(11):2077-2096. 2. Yin Y, et al. J Med Chem. 2015 Feb 26;58(4):1846-61. View Related Products by Target LIM Kinase (LIMK)
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Molecular Formula ]:
C22H21N5O2
[ Molecular Weight ]:
387.434
[ Exact Mass ]:
387.169525
[ LogP ]:
2.53
[ Index of Refraction ]:
1.738