3-Methylglutaric acid-d4

Names

[ CAS No. ]:
1219798-68-1

[ Name ]:
3-Methylglutaric acid-d4

[Synonym ]:
β-Methylglutaric acid
b-methyl-Glutaric acid
3-methyl-Glutaric acid
3-Methylglutaric acid
Pentanedioic acid, 3-methyl-
β-methyl-Glutaric acid
3-Methylglutarate
3-Methylpentanedioic acid
b-Methylglutaric acid
2-Methylglutaric acid

Biological Activity

[Description]:

3-Methylglutaric acid-d4 is the deuterium labeled 3-Methylglutaric acid[1]. 3-Methylglutaric acid, a leucine metabolite, is a conspicuous C6 dicarboxylic organic acid classically associated with two distinct leucine pathway enzyme deficiencies, 3-hydroxy-3-methylglutaryl CoA lyase (HMGCL) and 3-methylglutaconyl CoA hydratase (AUH)[2][3].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Barich DH, et al. 3-Methylglutaric acid as a 13C solid-state NMR standard. Solid State Nucl Magn Reson. 2006 Oct;30(3-4):125-9.  

[3]. Dylan E Jones, et al. 3-Methylglutaric acid in energy metabolism. Clin Chim Acta. 2020 Mar;502:233-239.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
299.0±13.0 °C at 760 mmHg

[ Molecular Formula ]:
C6H10O4

[ Molecular Weight ]:
146.141

[ Flash Point ]:
148.8±16.3 °C

[ Exact Mass ]:
146.057907

[ LogP ]:
-0.69

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.474

Related Compounds