3-Pyridylacetic acid-d4 hydrochloride

Names

[ CAS No. ]:
1219802-37-5

[ Name ]:
3-Pyridylacetic acid-d4 hydrochloride

[Synonym ]:
3-Pyridinyl(2H3)acetic acid (2H)hydrochloride (1:1)
Pyridin-3-yl(2H3)acetic acid (2H)hydrochloride (1:1)
3-Pyridineacetic-d2 acid-d, hydrochloride-d (1:1)

Biological Activity

[Description]:

3-Pyridylacetic acid-d4 (hydrochloride) is the deuterium labeled 3-Pyridylacetic acid hydrochloride[1]. 3-Pyridineacetic acid hydrochloride is a higher homologue of nicotinic acid, a breakdown product of nicotine (and other tobacco alkaloids)[2][3].

[Related Catalog]:

Research Areas >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. GINOULHIAC E, et al. 3-Pyridineacetic acid and nicotinic acid: blood levels, urinary elimination and excretion of nicotinic acid derivatives in man. Nature. 1962 Mar 10;193:948-9.  

[3]. Zwickenpflug W, et al. Metabolism of myosmine in Wistar rats. Drug Metab Dispos. 2005 Nov33(11):1648-56.  

Chemical & Physical Properties

[ Molecular Formula ]:
C7H4D4ClNO2

[ Molecular Weight ]:
177.622

[ Exact Mass ]:
177.049469

Related Compounds