RSL3

Names

[ CAS No. ]:
1219810-16-8

[ Name ]:
RSL3

[Synonym ]:
1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-, methyl ester, (1S,3R)-
Methyl (1S,3R)-2-(chloroacetyl)-1-[4-(methoxycarbonyl)phenyl]-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylate
RSL3
RSL3 (1S,3R-)

Biological Activity

[Description]:

RSL3 (1S,3R-) is a glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 10 μM in cellular assay.

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Christina Schott et al. Oncogenic RAS Mutants Confer Resistance of RMS13 Rhabdomyosarcoma Cells to Oxidative Stress-Induced Ferroptotic Cell Death.Front Oncol. 2015, 5: 131.

[2]. Michel Weiwer et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorganic & Medicinal Chemistry Letters 22 (2012) 1822-1826.

[3]. Wan Seok Yang et al. Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells. Chem Biol, 2008 Mar, 15(3): 234-245.

[Related Small Molecules]

AZD5904 | PF-06282999 | Tinoridine hydrochloride | Verdiperstat

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
641.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₁ClN₂O₅

[ Molecular Weight ]:
440.876

[ Flash Point ]:
341.6±31.5 °C

[ Exact Mass ]:
440.113892

[ LogP ]:
3.07

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.636

[ Storage condition ]:
2-8°C

RSL3

Names

Biological Activity

Chemical & Physical Properties

Related Compounds