4-CPA

Names

[ CAS No. ]:
122-88-3

[ Name ]:
4-CPA

[Synonym ]:
parachlorophenoxyacetic acid
Sure-Set
tomatofix
QV1OR DG
4-CPA
EINECS 204-581-3
Acetic acid, (4-chlorophenoxy)-
Acetic acid, 2-(4-chlorophenoxy)-
marks4-cpa
MFCD00004305
4-Chlorophenoxyacetic acid
4-ChFU
2-(4-Chlorophenoxy)acetic acid
4-CP
(4-Chlorophenoxy)acetic acid

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
315.2±17.0 °C at 760 mmHg

[ Melting Point ]:
157-159 °C

[ Molecular Formula ]:
C₈H₇ClO₃

[ Molecular Weight ]:
186.592

[ Flash Point ]:
144.4±20.9 °C

[ Exact Mass ]:
186.008377

[ PSA ]:
46.53000

[ LogP ]:
2.03

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.558

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AG0175000

CHEMICAL NAME :: Acetic acid, (p-chlorophenoxy)-

CAS REGISTRY NUMBER :: 122-88-3

BEILSTEIN REFERENCE NO. :: 1211804

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C8-H7-Cl-O3

MOLECULAR WEIGHT :: 186.60

WISWESSER LINE NOTATION :: QV1OR DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 680 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 10 mmol/L

REFERENCE :: ZYDXDM Zhejiang Yike Daxue Xuebao. Journal of Zhejiang Medical University. (Zhejiang Yike Daxue, Yan'an Lu, Hanzhou, Zhejiang, Peop. Rep. China) V.1- 1972(?)- Volume(issue)/page/year: 13(2),74,1984 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S22

[ RIDADR ]:
2811

[ WGK Germany ]:
1

[ RTECS ]:
AG0175000

[ HS Code ]:
2916399014

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2916399014

[ Summary ]:
2916399014 。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

Articles

Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3.

J. Med. Chem. 52 , 6931-5, (2009)

We show that phenoxyauxin herbicides and lipid-lowering fibrates inhibit human but not rodent T1R3. T1R3 as a coreceptor in taste cells responds to sweet compounds and amino acids; in endocrine cells ...

Amphiphilic blockers punch through a mutant CLC-0 pore.

J. Gen. Physiol. 133(1) , 59-68, (2009)

Intracellularly applied amphiphilic molecules, such as p-chlorophenoxy acetate (CPA) and octanoate, block various pore-open mutants of CLC-0. The voltage-dependent block of a particular pore-open muta...

Molecular modeling of p-chlorophenoxyacetic acid binding to the CLC-0 channel.

Biochemistry 42(18) , 5176-85, (2003)

Molecular simulation techniques were applied to predict the interaction of the CLC-0 Cl(-) channel and the channel-blocking molecule p-chlorophenoxyacetic acid (CPA). A three-dimensional model of the ...