ML197

ML197 is a potent, selective small molecule inhibitor of Cdc2-like kinases (CLK) and DYRK with IC50 of 96/40/206 nM for CLK1/CLK4/Dyrk1A, respectively; inhibits CLK2, CLK3 and Dyrk1B with IC50 of 1327, 7448 and 1510 nM, extends intracellular NKX3.1 half-life in LNCaP prostate cancer cells;

References 1. Rosenthal AS, et al. Bioorg Med Chem Lett. 2011 May 15;21(10):3152-8. 2. Ewton DZ, et al. Mol Cancer Ther. 2011 Nov;10(11):2104-14. 3. Rosenthal AS, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. View Related Products by Target Cdc2-like Kinase (CLK)