Corazonin

Names

[ Name ]:
Corazonin

[Synonym ]:
PYR-TFQYSRGWTN-NH2
GLP-THR-PHE-GLN-TYR-SER-ARG-GLY-TRP-THR-ASN-NH2
PGLU-THR-PHE-GLN-TYR-SER-ARG-GLY-TRP-THR-ASN-NH2
PYR-THR-PHE-GLN-TYR-SER-ARG-GLY-TRP-THR-ASN-NH2
MFCD00133199

Biological Activity

[Description]:

Corazonin is a highly conserved neuropeptide hormone of wide-spread occurrence in insects, serves a central regulator of caste identity and behavior in social insects. Corazonin is also preferentially expressed in workers and/or foragers from other social insect species[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

[In Vitro]

Corazonin 是由侧脑神经分泌细胞投射到心体-语料体复合体和腹侧神经束神经元中产生的[1]。 Corazonin 在卵母细胞中激发内向电流 (EC50=200 pM)，并导致 CHO细胞的发光响应 (EC50=75 pM)[1]。

[In Vivo]

Corazonin (5.4 ng/脑室; 注射法; 单剂量) 在过渡期的哈氏牙鲆个体中，抑制大脑中卵黄蛋白原的表达，并刺激类似工人的狩猎行为，同时抑制决斗和卵子沉积等斗兽类行为[2]。

[References]

[1]. Kim YJ, et al. Corazonin receptor signaling in ecdysis initiation. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6704-9.

[2]. Gospocic J, et al. The Neuropeptide Corazonin Controls Social Behavior and Caste Identity in Ants. Cell. 2017 Aug 10;170(4):748-759.e12.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₂H₈₄N₁₈O₁₈

[ Molecular Weight ]:
1369.44000

[ Exact Mass ]:
1368.62000

[ PSA ]:
607.98000

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ WGK Germany ]:
3