GX-936
Names
[ CAS No. ]:
1235406-09-3
[ Name ]:
GX-936
Biological Activity
[Description]:
GX-936 (PF 05196233) is a potent Nav1.7 inhibitor that binds to the activated state of voltage-sensor domain IV (VSD4), exhibits robust inhibition of the 1KαPMTX-evoked N1742K response with IC50 of 40 nM; inhibits Nav1.7 through a voltage-sensor trapping mechanism, likely by stabilizing inactivated states of the channel.
[References]
References 1. Ahuja S, et al. Science. 2015 Dec 18;350(6267):aac5464. 2. Chernov-Rogan T, et al. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E792-E801. View Related Products by Target Sodium Channel
Chemical & Physical Properties
[ Molecular Formula ]:
C24H20F3N7O3S2
[ Molecular Weight ]:
575.585