DS-5272
Names
[ CAS No. ]:
1235575-97-9
[ Name ]:
DS-5272
Biological Activity
[Description]:
A potent and orally active p53-MDM2 interaction inhibitor with IC50 of 2.4 nM; inhibits SJSA-1 cell proliferation with GI50 of 0.17 uM, demonstrates excellent antitumor efficacy on SJSA-1 xenografted models with high safety and good PK profiles.
[References]
References 1. Miyazaki M, et al. Bioorg Med Chem. 2015 May 15;23(10):2360-7. View Related Products by Target MDM2-p53
Chemical & Physical Properties
[ Molecular Formula ]:
C34H38Cl2F2N6O2S
[ Molecular Weight ]:
703.675