NC-005
Names
[ CAS No. ]:
1237540-74-7
[ Name ]:
NC-005
Biological Activity
[Description]:
A potent, specific immunoproteasome β5 subunit inhibitor with IC50 of 44 nM, 105 and 225-fold selectivity over β2i and β1i subunit, respecitvely; shows cytotoxicity against multiple myeloma cells with IC50 of 30 nM-1.5 uM.
[References]
References 1. Britton M, et al. Chem Biol. 2009 Dec 24;16(12):1278-89. 2. de Bruin G, et al. J Med Chem. 2014 Jul 24;57(14):6197-209. View Related Products by Target Proteasome
Chemical & Physical Properties
[ Molecular Formula ]:
C40H45N3O6
[ Molecular Weight ]:
663.815