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RP-5063

Names

[ CAS No. ]:
1239729-06-6

[ Name ]:
RP-5063

[Synonym ]:
6-{4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy}-2H-1,4-benzoxazin-3(4H)-one
Brilaroxazine
2H-1,4-Benzoxazin-3(4H)-one, 6-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-

Biological Activity

[Description]:

RP-5063 (Brilaroxazine) is a multimodal dopamine and serotonin modulator with partial agonist activity at DA D2, D3, D4, 5-HT1A, and 5-HT2ARs, and antagonist activity at 5-HT2B, 5-HT6 and 5-HT7Rs; produces dose-dependent reductions in pulmonary blood vessel wall thickness and proportion of muscular vessels, blocks MCT-induced increases in the plasma cytokines TNFα, IL-1β, and IL-6 in vivo; prevents Sugen 5416-hypoxia-induced pulmonary arterial hypertension in rats; improves declarative memory and psychosis in mouse models of schizophrenia. Schizophrenia Phase 2 Clinical

[References]

References 1. Bhat L, et al. Eur J Pharmacol. 2017 Sep 5;810:83-91. 2. Rajagopal L, et al. Behav Brain Res. 2017 Aug 14;332:180-199. 3. Bhat L, et al. Eur J Pharmacol. 2017 Sep 5;810:92-99. View Related Products by Target Dopamine Receptor Schizophrenia

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
643.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H25Cl2N3O3

[ Molecular Weight ]:
450.358

[ Flash Point ]:
342.7±31.5 °C

[ Exact Mass ]:
449.127289

[ LogP ]:
4.79

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.593

Related Compounds