FUBP1-IN-2

Names

[ CAS No. ]:
1242862-71-0

[ Name ]:
FUBP1-IN-2

Biological Activity

[Description]:

FUBP1-IN-2 (compound 9) is a potent FUBP1 (far upstream binding protein 1) inhibitor. FUBP1-IN-2 inhibits the KH4 FUBP1-FUSE interaction in a gel shift assay. FUBP1-IN-2 binds to FUBP1 in a ChIP assay. FUBP1-IN-2 reduces both c-Myc mRNA and protein expression, increases p21 mRNA and protein expression, and depletes intracellular polyamines[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Apoptosis >> c-Myc

[In Vitro]

FUBP1-IN-2 (compound 9) does not inhibit 3 H-spermidine uptake yet works synergistically with Eflornithine (HY-B0744) to limit cell growth in the presence of exogenous spermidine[1].

[References]

[1]. Dobrovolskaite A, et al. Discovery of Anthranilic Acid Derivatives as Difluoromethylornithine Adjunct Agents That Inhibit Far Upstream Element Binding Protein 1 (FUBP1) Function. J Med Chem. 2022 Nov 24;65(22):15391-15415.  

Chemical & Physical Properties

[ Molecular Formula ]:
C26H26ClN3O4

[ Molecular Weight ]:
479.96

Related Compounds