CP21R7

Names

[ Name ]:
CP21R7

[Synonym ]:
3-(3-Aminophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-
CP21R7
CP21
CP-21R7

Biological Activity

[Description]:

CP21R7 is potent GSK-3β inhibitor, with an IC50 of 1.8 nM; CP21R7 also shows inhibitory activitiy against PKCα, with an IC50 of 1900 nM.

[Related Catalog]:

Research Areas >> Cancer

[Target]

GSK-3β:1.8 nM (IC50)

PKCα:1900 nM (IC50)

[In Vitro]

CP21R7 (Compound 9) is a selective inhibitor of GSK-3β, with an IC50 of 1.8 nM; the IC50 of CP21R7 against PKCα is 1900 nM[1]. CP21R7 (CP21, 3 μM) potently activates canonical Wnt signaling with highest activity. CP21 significantly increases total levels of intracellular β-catenin. CP21 combined with BMP4 induces commitment of hPSCs towards mesoderm[2].

[References]

[1]. Gong L, et al. Discovery of potent and bioavailable GSK-3beta inhibitors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1693-6.

[2]. Patsch C, et al. Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Nat Cell Biol. 2015 Aug;17(8):994-1003.

[Related Small Molecules]

CHIR-99021 (CT99021) | SB216763 | TWS119 | LY2090314 | Tideglusib | BIO | Kenpaullone | AR-A014418 | AZD1080 | CHIR-98014 | AZD2858 | Indirubin-3'-monoxime | SB 415286 | Bikinin | RGB-286638

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
627.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₅N₃O₂

[ Molecular Weight ]:
317.341

[ Flash Point ]:
333.2±31.5 °C

[ Exact Mass ]:
317.116425

[ LogP ]:
2.40

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.714

[ Storage condition ]:
-20℃