N-Boc-serinol

Names

[ Name ]:
N-Boc-serinol

[Synonym ]:
tert-butyl N-(1,3-dihydroxypropan-2-yl)carbamate
2-Methyl-2-propanyl (1,3-dihydroxy-2-propanyl)carbamate
Carbamic acid, N-[2-hydroxy-1-(hydroxymethyl)ethyl]-, 1,1-dimethylethyl ester
1,1-Dimethylethyl [2-hydroxy-1-(hydroxymethyl)ethyl]carbamate

Biological Activity

[Description]:

N-Boc-serinol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
363.0±32.0 °C at 760 mmHg

[ Melting Point ]:
85-89ºC

[ Molecular Formula ]:
C₈H₁₇NO₄

[ Molecular Weight ]:
191.225

[ Flash Point ]:
173.4±25.1 °C

[ Exact Mass ]:
191.115753

[ PSA ]:
78.79000

[ LogP ]:
0.30

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.476

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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