AZD-5248

Names

[ Name ]:
AZD-5248

[Synonym ]:
4-Amino-N-[(1S)-1-cyano-2-(4'-cyano-4-biphenylyl)ethyl]tetrahydro-2H-pyran-4-carboxamide
2H-Pyran-4-carboxamide, 4-amino-N-[(1S)-1-cyano-2-(4'-cyano[1,1'-biphenyl]-4-yl)ethyl]tetrahydro-

Biological Activity

[Description]:

AZD-5248 is a potent, selective, first generation, oral inhibitor of dipeptidyl peptidase 1 (DPP1).

[References]

References 1. Bragg RA, et al. Chem Res Toxicol. 2015 Oct 19;28(10):1991-9. View Related Products by Target Dipeptidyl Peptidase (DPP)

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
685.2±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₂N₄O₂

[ Molecular Weight ]:
374.436

[ Flash Point ]:
368.2±31.5 °C

[ Exact Mass ]:
374.174286

[ LogP ]:
1.40

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.625

AZD-5248

Names

Biological Activity

Chemical & Physical Properties

Related Compounds