Sarsasapogenin
Names
[ CAS No. ]:
126-19-2
[ Name ]:
Sarsasapogenin
[Synonym ]:
Spirostan-3-ol, (3β,5β,25S)-
PERIGENIN
5β-Spirostan-3β-ol, (25S)-
PARIGENIN
MFCD00075412
SARSAPOGENINE
EINECS 204-776-3
(2S,4aS,4bS,5'S,6aS,6bR,7S,8R,9aS,10aS,10bR,12aR)-4a,5',6a,7-Tetramethyldocosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-8,2'-pyran]-2-ol
Sasarasapogenin
(2S,4aS,4bS,5'S,6aS,6bR,7S,8R,9aS,10aS,10bR,12aR)-4a,5',6a,7-Tétraméthyldocosahydrospiro[naphto[2',1':4,5]indéno[2,1-b]furane-8,2'-pyran]-2-ol
(3β,5β,25S)-Spirostan-3-ol
Yucca Extract
SARSAPOGENIN
(25S)-5beta-spirostan-3beta-ol
(3b,5b,25S)-Spirostan-3-ol
Yucca foam extract
sarsagenin
Sarsasapogenin
(25S)-Spirostan-3β-ol
Biological Activity
[Description]:
[Related Catalog]:
[Target]
NF-κB
[In Vitro]
[In Vivo]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
516.6±20.0 °C at 760 mmHg
[ Melting Point ]:
194°C
[ Molecular Formula ]:
C27H44O3
[ Molecular Weight ]:
416.637
[ Flash Point ]:
266.2±21.8 °C
[ Exact Mass ]:
416.329041
[ PSA ]:
38.69000
[ LogP ]:
6.21
[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C
[ Index of Refraction ]:
1.552
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
T+
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Steroids 77(5) , 534-41, (2012)
The regioselective opening of the F ring of 22-oxo-23-spiroketals using a saturated solution of HCl in acetic anhydride yielded novel cholestanic frameworks with pyranone or cyclopentenone E rings. Th...
Deacylation reactions of 20-acetyl dinorcholanic lactones and 20,23-diacetyl furost-22-enes.Steroids 75(3) , 240-4, (2010)
We report the deacylation of (20R)-20-acetyl-23,24-dinorcholanic lactones by hydrazine hydrate, under microwave irradiation in high yields. The elimination of the 20-acetyl group proceeded with retent...
Sarsasapogenin induces apoptosis via the reactive oxygen species-mediated mitochondrial pathway and ER stress pathway in HeLa cells.Biochem. Biophys. Res. Commun. 441(2) , 519-24, (2013)
Sarsasapogenin is a sapogenin from the Chinese medical herb Anemarrhena asphodeloides Bunge. In the present study, we revealed that sarsasapogenin exhibited antitumor activity by inducing apoptosis in...