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Norgestimate-d6

Names

[ CAS No. ]:
1263194-12-2

[ Name ]:
Norgestimate-d6

[Synonym ]:
NORGESTIMATE-D6
MFCD18385033

Biological Activity

[Description]:

Norgestimate D6 is the deuterium labeled Norgestimate. Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Progesterone Receptor
Research Areas >> Endocrinology

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Stanczyk FZ, et al. All progestins are not created equal. Steroids. 2003 Nov;68(10-13):879-90.

[3]. Phillips A, et al. Preclinical evaluation of norgestimate, a progestin with minimal androgenic activity. Am J Obstet Gynecol. 1992 Oct;167(4 Pt 2):1191-6.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
497.9±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H25D6NO3

[ Molecular Weight ]:
375.534

[ Flash Point ]:
254.9±28.7 °C

[ Exact Mass ]:
375.268066

[ LogP ]:
5.00

[ Vapour Pressure ]:
0.0±2.9 mmHg at 25°C

[ Index of Refraction ]:
1.611

Related Compounds