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(+/-)-JQ1

Names

[ CAS No. ]:
1268524-69-1

[ Name ]:
(+/-)-JQ1

[Synonym ]:
MFCD23726614

Chemical & Physical Properties

[ Density]:
1.33±0.1 g/cm3(Predicted)

[ Boiling Point ]:
610.4±65.0 °C(Predicted)

[ Molecular Formula ]:
C23H25ClN4O2S

[ Molecular Weight ]:
456.98800

[ Exact Mass ]:
456.13900

[ PSA ]:
97.61000

[ LogP ]:
4.96690

[ Appearance of Characters ]:
powder,white to beige

MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Precursor & DownStream

Articles

Selective inhibition of BET bromodomains.

Nature 468(7327) , 1067-73, (2010)

Epigenetic proteins are intently pursued targets in ligand discovery. So far, successful efforts have been limited to chromatin modifying enzymes, or so-called epigenetic 'writers' and 'erasers'. Pote...

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer.

Nature 510(7504) , 278-82, (2014)

Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb to the disease. Progression to CRPC after androgen ablation therapy is predominantly driven by deregulated and...


More Articles


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