Glutathione arsenoxide

Names

[ Name ]:
Glutathione arsenoxide

Biological Activity

[Description]:

Glutathione arsenoxide (GSAO) is a potential anticancer agent and a tumour metabolism inhibitor. Glutathione arsenoxide targets Mitochondrial endomycin nucleotide transferase (ANT). Glutathione arsenoxide causes cell proliferation arrest and cell death. Glutathione arsenoxide can be used to identify cell-surface proteins, such as Protein disulphide isomerase[1].

[Related Catalog]:

Research Areas >> Cancer

[Target]

Mitochondrial endomycin nucleotide transferase (ANT), Protein disulphide isomerase (PDI)[1]

[References]

[1]. Park D, et al. The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase. Cancer Cell Int. 2012 Mar 26;12(1):11.

[2]. Habeck M. Australian scientists design novel antiangiogenic weapon[J]. The Lancet Oncology, 2000, 1(4): 199.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₅AsN₄O₉S

[ Molecular Weight ]:
548.40

Related Compounds

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