Phthalic acid mono-2-ethylhexyl ester-d4

Names

[ Name ]:
Phthalic acid mono-2-ethylhexyl ester-d4

[Synonym ]:
2-{[(2-Ethylhexyl)oxy]carbonyl}(2H4)benzoic acid
1,2-Benzene-d4-dicarboxylic acid, mono(2-ethylhexyl) ester

Biological Activity

[Description]:

Phthalic acid mono-2-ethylhexyl ester-d4 is a deuterium labeled Phthalic acid mono-2-ethylhexyl ester (HY-W018392). Phthalic acid mono-2-ethylhexyl ester (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP), which inhibits the 17, 20 lyase activity of CYP17[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246.

[2]. Bai J, et al. Mono-2-ethylhexyl phthalate induces the expression of genes involved in fatty acid synthesis in HepG2 cells. Environ Toxicol Pharmacol. 2019 Jul;69:104-111.

[3]. Chauvigné F, et al. Mono-(2-ethylhexyl) phthalate directly alters the expression of Leydig cell genes and CYP17 lyase activity in cultured rat fetal testis. PLoS One. 2011;6(11):e27172.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
408.9±28.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₈D₄O₄

[ Molecular Weight ]:
282.37

[ Flash Point ]:
144.1±17.5 °C

[ Exact Mass ]:
282.176910

[ LogP ]:
4.66

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.517