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Melarsomine

Names

[ CAS No. ]:
128470-15-5

[ Name ]:
Melarsomine

[Synonym ]:
Melarsomine
Melarsominum [INN-Latin]
Melarsomina
Melarsomina [INN-Spanish]
Bis(2-aminoethyl) p-((4,6-diamino-s-triazin-2-yl)amino)dithiobenzenearsonite
Melarsomine (INN)
Melarsominum
UNII-374GJ0S41A

Biological Activity

[Description]:

Melarsomine is a trivalent arsenical compound used as an adulticide. Melarsomine can be used for the reserach of canine heartworm disease and other helminth infections[1][2].

[Related Catalog]:

Research Areas >> Infection

[In Vivo]

Melarsomine (2.5 mg/kg; deep i.m. injection) combined with Doramectin managed to clear the D. repens infection in dogs[1]. Melarsomine (0.25 mg/kg; deep i.m. injection) can cure T. evansi infection in camels[2]. Melarsomine (0.5 mg/kg; deep i.m. injection) can cure T. evansi infection in dairy cattle in Thailand[2].

[References]

[1]. Baneth G, et, al. Dirofilaria repens infection in a dog: diagnosis and treatment with melarsomine and doramectin. Vet Parasitol. 2002 Apr 30;105(2):173-8.

[2]. Desquesnes M, et, al. An evaluation of melarsomine hydrochloride efficacy for parasitological cure in experimental infection of dairy cattle with Trypanosoma evansi in Thailand. Parasitology. 2011 Aug;138(9):1134-42.

Chemical & Physical Properties

[ Boiling Point ]:
678.1ºC at 760mmHg

[ Molecular Formula ]:
C13H21AsN8S2

[ Molecular Weight ]:
428.41100

[ Flash Point ]:
363.9ºC

[ Exact Mass ]:
428.05500

[ PSA ]:
205.38000

[ LogP ]:
2.49460

[ Vapour Pressure ]:
3.03E-18mmHg at 25°C

Related Compounds