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(Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) trifluoroacetate salt

Names

[ CAS No. ]:
129622-68-0

[ Name ]:
(Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) trifluoroacetate salt

[Synonym ]:
L-Leucyl-L-leucyl-L-histidyl-L-asparaginyl-L-leucyl-D-tryptophyl-L-lysyl-L-seryl-L-isoleucyl-L-glutaminyl-L-α-aspartyl-L-leucyl-L-arginyl-L-arginyl-L-arginyl-L-phenylalanyl-L-phenylalanyl-L-leucyl -L-histidyl-L-histidyl-L-leucyl-L-isoleucyl-L-alanyl-L-α-glutamyl-L-isoleucyl-L-histidyl-L-threonyl-L-alaninamide
MFCD00214657
L-Alaninamide, L-leucyl-L-leucyl-L-histidyl-L-asparaginyl-L-leucyl-D-tryptophyl-L-lysyl-L-seryl-L-isoleucyl-L-glutaminyl-L-α-aspartyl-L-leucyl-L-arginyl-L-arginyl-L-arginyl-L-phenylalanyl-L-phenyl alanyl-L-leucyl-L-histidyl-L-histidyl-L-leucyl-L-isoleucyl-L-alanyl-L-α-glutamyl-L-isoleucyl-L-histidyl-L-threonyl-

Biological Activity

[Description]:

(Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) is a potent PTH-1R antagonist[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[Target]

PTH1R


[References]

[1]. Nutt RF, et al. Removal of partial agonism from parathyroid hormone (PTH)-related protein-(7-34)NH2 by substitution of PTH amino acids at positions 10 and 11. Endocrinology. 1990 Jul;127(1):491-3.  

[2]. Portal-Núñez S, et al. Parathyroid hormone-related protein exhibits antioxidant features in osteoblastic cells through its N-terminal and osteostatin domains. Bone Joint Res. 2018 Jan;7(1):58-68.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C162H254N50O36

[ Molecular Weight ]:
3478.06

[ Exact Mass ]:
3475.958252

[ LogP ]:
0.51

[ Index of Refraction ]:
1.664

Related Compounds