Medphalan
Names
[ CAS No. ]:
13045-94-8
[ Name ]:
Medphalan
[Synonym ]:
4-[Bis-(2-chlor-aethyl)-amino]-D-phenylalanin
(R)-2-amino-3-(4-(bis(2-chloroethyl)amino)phenyl)propanoic acid
D-Melphalan
Lopac-M-2011
4-(bis(2-chloroethyl)amino)-L-phenylalanine
4-[bis-(2-chloro-ethyl)-amino]-D-phenylalanine
Medphalan
3026 C. B.
p-Di(2-chloroethyl)amino-d-phenylalanine
MFCD01674289
Melphalan Impurity 12
Chemical & Physical Properties
[ Density]:
1.32g/cm3
[ Boiling Point ]:
473.1ºC at 760 mmHg
[ Melting Point ]:
182-183ºC (decomp)
[ Molecular Formula ]:
C13H18Cl2N2O2
[ Molecular Weight ]:
305.20000
[ Flash Point ]:
239.9ºC
[ Exact Mass ]:
304.07500
[ PSA ]:
66.56000
[ LogP ]:
2.62530
[ Vapour Pressure ]:
9.33E-10mmHg at 25°C
[ Index of Refraction ]:
1.596
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AY3370000
- CHEMICAL NAME :
- Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, D-
- CAS REGISTRY NUMBER :
- 13045-94-8
- LAST UPDATED :
- 199510
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C13-H18-Cl2-N2-O2
- MOLECULAR WEIGHT :
- 305.23
- WISWESSER LINE NOTATION :
- QVYZ1R DN2G2G -D
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intracerebral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 113 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 120 mg/kg/9W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors
- TYPE OF TEST :
- Specific locus test
MUTATION DATA
- TEST SYSTEM :
- Insect - Drosophila melanogaster
- DOSE/DURATION :
- 10 mmol/L
- REFERENCE :
- JOGNAU Journal of Genetics. (Belghoria, India) V.1-63, 1910-77. Discontinued. Volume(issue)/page/year: 54,146,1956 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 9,167,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 9,167,1975 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987
Safety Information
[ HS Code ]:
2922499990
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2922499990
[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%