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VU0360172

Names

[ CAS No. ]:
1310012-12-4

[ Name ]:
VU0360172

Biological Activity

[Description]:

VU0360172 is a potent and selective mGlu5 receptor positive allosteric modulator with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR
Research Areas >> Neurological Disease

[Target]

EC50: 16 nM (mGlu5 receptor)[1] Ki: 195 nM (mGlu5 receptor)[1]


[References]

[1]. Zuena AR, et al. In Vivo Non-radioactive Assessment of mGlu5 Receptor-Activated Polyphosphoinositide Hydrolysis in Response to Systemic Administration of a Positive Allosteric Modulator. Front Pharmacol. 2018 Jul 31;9:804.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H15FN2O

[ Molecular Weight ]:
294.32

Related Compounds