ML115

ML115 is a novel "bone-seeking" bisphosphonate based MMP-2 specific inhibitor (BMMPI), spares the activity of other MMPs including MMP-9; affects the viability of breast cancer cell lines and osteoclast precursors, but not osteoblasts in vitro, significantly reduces tumor growth and tumor-associated bone destruction in bone metastatic models (PyMT-R221A and 4T1); also decreases multiple myeloma burden and protect against cancer-induced osteolysis, specifically inhibits in the multiple myeloma-bone microenvironment.

References 1. Tauro M, et al. Mol Cancer Ther. 2017 Mar;16(3):494-505. 2. Shay G, et al. Oncotarget. 2017 Jun 27;8(26):41827-41840. 3. Rubino MT, et al. ChemMedChem. 2011 Jul 4;6(7):1258-68. View Related Products by Target Matrix Metalloproteinase (MMP)