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RU-505

Names

[ CAS No. ]:
1314206-29-5

[ Name ]:
RU-505

[Synonym ]:
N-Benzyl-N-[2-(dimethylamino)ethyl]-7-(4-fluorophenyl)-2-(2-methyl-2-propanyl)pyrazolo[1,5-a]pyrimidine-5-carboxamide
MFCD06620515
Pyrazolo[1,5-a]pyrimidine-5-carboxamide, N-[2-(dimethylamino)ethyl]-2-(1,1-dimethylethyl)-7-(4-fluorophenyl)-N-(phenylmethyl)-
RU-505

Biological Activity

[Description]:

RU-505 is an effective β-amyloid (Aβ)-fibrinogen interaction inhibitor with IC50s of 5.00 and 2.72 μM in fluorescence polarization (FP) and AlphaLISA assays, respectively. RU-505 is highly permeable to the BBB. RU-505 reduces cerebral amyloid angiopathy (CAA). RU-505 can be used for the research of Alzheimer’s disease (AD)[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Hyung Jin Ahn, et al. A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer's disease mice. J Exp Med. 2014 Jun 2;211(6):1049-62.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H32FN5O

Related Compounds