HG6-64-1

Names

[ Name ]:
HG6-64-1

[Synonym ]:
N-{4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl}-3-[(E)-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-5-yl)vinyl]-4-methylbenzamide
Benzamide, N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[(E)-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-5-yl)ethenyl]-4-methyl-
hg6-64-1

Biological Activity

[Description]:

HG6-64-1 is a potent and selective B-Raf inhibitor extracted from patent WO 2011090738 A2, example 9 (XI-1); has a IC50 of 0.09 μM on B-raf V600E transformed Ba/F3 cells.

[Related Catalog]:

Research Areas >> Cancer

[Target]

B-RafV600E:0.09 μM (IC50, in Ba/F3 cells)

[References]

[1]. WO 2011090738 A2

[Related Small Molecules]

PLX8394 | Doramapimod (BIRB 796) | PLX-4720 | LGX 818 | LY 3009120 | GW5074 | RAF265 (CHIR-265) | AZ 628 | RAF709 | CEP-32496 | GDC-0879 | LXH254 | TAK-632 | PLX7904 | RO 5126766

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₃₂H₃₄F₃N₅O₂

[ Molecular Weight ]:
577.640

[ Exact Mass ]:
577.266479

[ PSA ]:
73.49000

[ LogP ]:
6.24

[ Index of Refraction ]:
1.651

[ Storage condition ]:
2-8℃

HG6-64-1

Names

Biological Activity

Chemical & Physical Properties

Related Compounds