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Citarinostat

Names

[ CAS No. ]:
1316215-12-9

[ Name ]:
Citarinostat

[Synonym ]:
2-[(2-Chlorophenyl)(phenyl)amino]-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide
Citarinostat
2-((2-chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxohepl)pyrimidine-5-carboxamide
5-Pyrimidinecarboxamide, 2-[(2-chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-
2-((2-chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide
ACY-241
UNII:441P620G3P
ACY-241 Avi Tini

Biological Activity

[Description]:

Citarinostat is a HDAC6 specific inhibitor, with IC50 of 4 nM and 76 nM for HDAC6 and HDAC3, respectively.IC50 value: 4 nM (HDAC6), 76 nM (HDAC3)Target: HDACThe detailed information please refer to WO2015061684A1 and 2015054197A1.

[Related Catalog]:

Research Areas >> Cancer

[Target]

HDAC6:2.6 nM (IC50)

HDAC1:35 nM (IC50)

HDAC2:45 nM (IC50)

HDAC3:46 nM (IC50)

HDAC8:137 nM (IC50)

HDAC7:7300 nM (IC50)


[References]

[1]. Huang P, et al. Selective HDAC inhibition by ACY-241 enhances the activity of paclitaxel in solid tumor models. Oncotarget. 2017 Jan 10;8(2):2694-2707.

[2]. From PCT Int. Appl. (2015), WO 2015054197 A1 20150416.


[Related Small Molecules]

Trichostatin A | Entinostat (MS-275) | Romidepsin (FK228, Depsipeptide) | Mocetinostat(MGCD0103) | Ricolinostat (ACY-1215) | Sodium butyrate | RGFP 966 | Quisinostat | Tubacin | DL-Sulforaphane | CUDC-907 | LMK 235 | CI-994 | Tubastatin A | Sodium phenylbutyrate

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C24H26ClN5O3

[ Molecular Weight ]:
467.948

[ Exact Mass ]:
467.172424

[ PSA ]:
107.45000

[ LogP ]:
1.80

[ Index of Refraction ]:
1.624

[ Storage condition ]:
-20℃

Related Compounds