Peptide P60
Names
[ CAS No. ]:
1319725-20-6
[ Name ]:
Peptide P60
Biological Activity
[Description]:
Peptide P60 (FOXP3 inhibitor P60) is a 15-mer synthetic peptide, cell-permeable inhibitor of FOXP3, binds specifically to FOXP3; inhibits murine and human-derived Treg and improves effector T cell stimulation, overcomes the inhibitory effect of FOXP3 on the activity of the transcription factors NF-κB and NFAT, inhibits upregulation of mRNA for Foxp3 and IL-10 on effector T cells and enhances mRNA for IFN-γ after anti-CD3 stimulation; induces a scurfy-like disease in newborn mice, improves vaccine efficacy in mice model of CT26 tumor and HCV infection.
[References]
References 1. Casares N, et al. J Immunol. 2010 Nov 1;185(9):5150-9. View Related Products by Target Other Targets
Chemical & Physical Properties
[ Molecular Formula ]:
C95H132N24O20S2
[ Molecular Weight ]:
1994.369