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Lopinavir-d8

Names

[ CAS No. ]:
1322625-54-6

[ Name ]:
Lopinavir-d8

[Synonym ]:
N-[(2S,4S,5S)-5-{[(2,6-Dimethylphenoxy)acetyl]amino}-4-hydroxy-1,6-diphenyl-2-hexanyl]-3-(2H3)methyl-2-(2-oxotetrahydro-1(2H)-pyrimidinyl)(2H5)butanamide
1(2H)-Pyrimidineacetamide-d, N-[(1S,3S,4S)-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-[1-(methyl-d3)ethyl-1,2,2,2-d4]-2-oxo-
Lopinavir-d8

Biological Activity

[Description]:

(rel)-Lopinavir-d8 ((rel)-ABT-378-d8)is the deuterium labeledLopinavir(HY-14588)[1]. Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity[2][3]. Lopinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 14.2 μM[4].

[Related Catalog]:

Research Areas >> Others

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
924.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C37H40D8N4O5

[ Molecular Weight ]:
636.85

[ Flash Point ]:
512.7±34.3 °C

[ Exact Mass ]:
636.412659

[ LogP ]:
6.26

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.577

Related Compounds