4-Fluorobenzyl isocyanate

[ Density]:
1.09g/cm3

[ Boiling Point ]:
205ºC at 760mmHg

[ Molecular Formula ]:
C₈H₆FNO

[ Molecular Weight ]:
151.13800

[ Flash Point ]:
74.7ºC

[ Exact Mass ]:
151.04300

[ PSA ]:
29.43000

[ LogP ]:
1.66150

[ Vapour Pressure ]:
0.256mmHg at 25°C

[ Index of Refraction ]:
n20/D 1.505(lit.)

[ Storage condition ]:
Store under Argon

Click to get detail MSDS

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S26-S36-S37-S39

[ RIDADR ]:
UN 2206 6.1/PG 3

[ WGK Germany ]:
3

Click to get detail synthetic route

Precursor

DownStream

Structure-based design of novel boronic acid-based inhibitors of autotaxin.

J. Med. Chem. 54 , 4619-4626, (2011)

Autotaxin (ATX) is a secreted phosphodiesterase that hydrolyzes the abundant phospholipid lysophosphatidylcholine (LPC) to produce lysophosphatidic acid (LPA). The ATX-LPA signaling axis has been impl...

Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor.

J. Pharmacol. Exp. Ther. 325(3) , 893-901, (2008)

Neuropeptide S (NPS) has been shown to modulate arousal, sleep wakefulness, anxiety-like behavior, and feeding after central administration of the peptide agonist to mice or rats. We report here the c...

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