VU0418506

Names

[ Name ]:
VU0418506

[Synonym ]:
1H-Pyrazolo[4,3-b]pyridin-3-amine, N-(3-chloro-4-fluorophenyl)-
MFCD30481312
N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine

Biological Activity

[Description]:

VU0418506 (VU 0418506) is a potent and selective mGlu4 positive allosteric modulator (PAM) with EC50 of 68 nM (hmGlu4); displays selectivity versus the Group I and Group II mGlu receptors and against mGlu7 and mGlu8; does not potentiate agonist-induced activity when mGlu2 and mGlu4 are heterodimerized; VU0418506 is clean against a panel of ion channels associated with cardiac toxicity and it negative in a mini-AMES assay with and without S9.

[References]

References 1. Engers DW, et al. ACS Chem Neurosci. 2016 Sep 21;7(9):1192-200. 2. Niswender CM, et al. ACS Chem Neurosci. 2016 Sep 21;7(9):1201-11. View Related Products by Target mGluR

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
467.0±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₂H₈ClFN₄

[ Molecular Weight ]:
262.670

[ Flash Point ]:
236.2±28.7 °C

[ Exact Mass ]:
262.042145

[ LogP ]:
4.47

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.743