Cdc7 inhibitor 7c
Names
[ CAS No. ]:
1330781-04-8
[ Name ]:
Cdc7 inhibitor 7c
[Synonym ]:
6-(3-Methyl-1H-pyrazol-4-yl)-2-(1-pyrrolidinylmethyl)thieno[3,2-d]pyrimidin-4(3H)-one
Thieno[3,2-d]pyrimidin-4(3H)-one, 6-(3-methyl-1H-pyrazol-4-yl)-2-(1-pyrrolidinylmethyl)-
Biological Activity
[Description]:
A highly potent, selective and time-dependent Cdc7 kinase inhibitor with IC50 of 0.7 nM with slow dissociation property, with 200-fold and >14,000-fold selectivity over CDK2 and ROCK1, respectively; exhibits significant time-dependent Cdc7 inhibition with slow dissociation kinetics, cellular pharmacodynamic (PD) effects, and COLO205 growth inhibition.
[References]
References 1. Kurasawa O, et al. Bioorg Med Chem. 2017 Jul 15;25(14):3658-3670. View Related Products by Target Cyclin-dependent Kinase (CDK)
Chemical & Physical Properties
[ Density]:
1.6±0.1 g/cm3
[ Molecular Formula ]:
C15H17N5OS
[ Molecular Weight ]:
315.393
[ Exact Mass ]:
315.115387
[ LogP ]:
1.71
[ Index of Refraction ]:
1.805