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H-HoArg-OH-d4

Names

[ CAS No. ]:
1332075-41-8

[ Name ]:
H-HoArg-OH-d4

[Synonym ]:
L-Lysine-4,4,5,5-d4, N6-(aminoiminomethyl)-
N6-Carbamimidoyl-L-(4,4,5,5-2H4)lysine
2-Amino-6-guanidinohexanoic Acid-d4 Dihydrochloride

Biological Activity

[Description]:

H-HoArg-OH-d4 is a deuterium labeled H-HoArg-OH (HY-W008385). H-HoArg-OH, a homologue arginine, is a strong inhibitor of human bone and liver alkaline phosphatase.

[Related Catalog]:

Research Areas >> Metabolic Disease

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246.  

[2]. Fishman W, et al. L-homoarginine; an inhibitor of serum "bone and liver" alkaline phosphatase. Clin Chim Acta. 1970 Aug;29(2):339-41.  

[3]. Atzler D, et al. L-homoarginine and cardiovascular disease. Curr Opin Clin Nutr Metab Care. 2015 Jan;18(1):83-8.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
376.3±52.0 °C at 760 mmHg

[ Melting Point ]:
>90° C (dec.)

[ Molecular Formula ]:
C7H12D4N4O2

[ Molecular Weight ]:
192.25

[ Flash Point ]:
181.4±30.7 °C

[ Exact Mass ]:
192.152435

[ LogP ]:
-1.86

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.587

Related Compounds