JNJ-42314415
Names
[ CAS No. ]:
1334165-90-0
[ Name ]:
JNJ-42314415
[Synonym ]:
Imidazo[1,2-a]pyrazine, 3-[6-(2-methoxyethyl)-3-pyridinyl]-2-methyl-8-(4-morpholinyl)-
3-[6-(2-Methoxyethyl)-3-pyridinyl]-2-methyl-8-(4-morpholinyl)imidazo[1,2-a]pyrazine
Biological Activity
[Description]:
JNJ-42314415(JNJ42314415) is a potent, selective, centrally active phosphodiesterase 10A (PDE10A) inhibitor with Ki of 35 nM for human recombinant PDE10A; inhibits rPDE10A with Ki of 64 nM, >100-fold selectivity over the other 10 PDE families; blocks conditioned avoidance behavior and behaviors induced by nondopaminergic stimulants (phencyclidine, scopolamine) more efficiently than D(2) receptor blockers, with less pronounced catalepsy; shows antipsychotic activity with an improved side-effect profile in vivo.
[References]
References 1. Megens AA, et al. J Pharmacol Exp Ther. 2014 Apr;349(1):138-54. View Related Products by Target Phosphodiesterase (PDE)
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Molecular Formula ]:
C19H23N5O2
[ Molecular Weight ]:
353.418
[ Exact Mass ]:
353.185181
[ LogP ]:
0.82
[ Index of Refraction ]:
1.654