YU142670

Names

[ Name ]:
YU142670

[Synonym ]:
YU142670
3-(4-pyridinyl)-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazole
3-(4-Pyridinyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
3-(Pyridin-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
MFCD06590438
1,2,4-Triazolo[3,4-b][1,3,4]thiadiazole, 3-(4-pyridinyl)-

Biological Activity

[Description]:

YU142670 is a highly specific, soluble OCRL/INPP5B inhibitor that directly interacts with the catalytic domain of INPP5B; induces enhanced actin polymerization and ruffle activity at the plasma membrane, increases the levels of PI(4,5)P2 in mouse embryonic fibroblasts or human dermal fibroblasts and inhibits the activity of over-expressed human OCRL in Cos-7 cells.

[References]

References 1. Pirruccello M, et al. ACS Chem Biol. 2014 Jun 20;9(6):1359-68. View Related Products by Target Protein Phosphatase/PTP

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Molecular Formula ]:
C₈H₅N₅S

[ Molecular Weight ]:
203.224

[ Exact Mass ]:
203.026566

[ LogP ]:
1.20

[ Index of Refraction ]:
1.898