N-(Trimethylsilyl)acetamide

Names

[ Name ]:
N-(Trimethylsilyl)acetamide

[Synonym ]:
EINECS 236-565-7
N-Trimethylsilylacetamide,TMS acetamide
N-(Trimethylsilyl)acetamide
N-Trimethylsilylacetamide
MFCD00008671
N-TMS-acetamide
Acetamide, N-(trimethylsilyl)-

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
190.2±0.0 °C at 760 mmHg

[ Melting Point ]:
46-49 °C(lit.)

[ Molecular Formula ]:
C₅H₁₃NOSi

[ Molecular Weight ]:
131.248

[ Flash Point ]:
57.2±0.0 °C

[ Exact Mass ]:
131.076645

[ PSA ]:
29.10000

[ LogP ]:
0.60

[ Vapour Pressure ]:
0.5±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.406

[ Storage condition ]:
Flammables area

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AD0250000

CHEMICAL NAME :: Acetamide, N-(trimethylsilyl)-

CAS REGISTRY NUMBER :: 13435-12-6

BEILSTEIN REFERENCE NO. :: 0741928

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C5-H13-N-O-Si

MOLECULAR WEIGHT :: 131.28

WISWESSER LINE NOTATION :: 1VM-SI-1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Immunological Including Allergic - decreased immune response

REFERENCE :: StoGD# Personal Communication from G.D. Stoner, Dept. of Community Medicine, School of Medicine, Univ. of California, La Jolla, CA 92037, May 25, 1975 Volume(issue)/page/year: 27MAY1975

Safety Information

[ Hazard Codes ]:
F:Flammable;Xi:Irritant;

[ Risk Phrases ]:
R11;R36/37/38

[ Safety Phrases ]:
S37/39-S26

[ RIDADR ]:
1325

[ WGK Germany ]:
3

[ RTECS ]:
AD0250000

[ Packaging Group ]:
III

[ Hazard Class ]:
4.1

[ HS Code ]:
2931900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2931900090

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

Articles

M.Vecchi and K.Kaiser

J. Chromatogr. A. 26 , 22, (1967)

D.R. Knapp

Handbook of Analytical Derivatization Reactions , (1979), 572

Quantitative analysis of ascorbic acid in tissues by gas-liquid chromatography.

Anal. Biochem. 43 , 401, (1971)